P-53: Protective Effect of Alcoholic Extract of Grape Seeds on Spermatogenesis Defects Induced by Dexamehasone

Authors

  • Salavatchi E
Abstract:

Background: Exposure to glucocorticoids such as dexamethasone (Dex) leads to numerous changes in various biological systems including the reproductive system. The present study investigates the efficacy of Alcoholic extract of grape seeds, an active component of turmeric, to attenuate Dex-induced spetmatogenic defects in the mouse testicles. Materials and Methods: A total of 32 male mice were divided into four groups (8 mice each). The first group served as control and received corn oil only for 25 days. Mice of the second group received Dex at the dose of 7 mg/kg body weight by i.p. injection for 7 days. Mice of the third group received Alcoholic extract of grape seeds at a dose of 40 ml/kg body weight. The fourth group received Alcoholic extract of grape seeds at the dose of 40 mg/kg for 25 days and Dex at the same dose of the second group was injected during the last 7 (18 to 25) days. Statistical significance was determined using one-way analysis of variance (ANOVA) followedby Tukey-Kramer multiple comparison tests. A p<0.05 denoted the presence of a statistically significant difference. Results: Testicular histopathology, morphometric analysis and immunohistochemistry assessments were performed for evaluation of the Dex and Alcoholic extract of grape seeds effects on testicular germ cells. There was marked staining for bcl-2, an important antiapoptotic factor, expression with Alcoholic extract of grape seeds +Dex compared with the Dex groups. Dex caused epithelial vacuolization, sloughing of germ cells, reduction of seminiferous tubule diameter, and significant maturation arrest (p<0.05). Alcoholic extract of grape seeds +Dex treatments showed significantly prevented these histopathologic changes (p<0.05). Conclusion: It is concluded that, Alcoholic extract of grape seeds may improve the adverse effects of Dex in the mouse testicular tissue by inducing anti-apoptotic mechanism.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

P-42: Protective Effect of Curcumin on Spermatogenesis Defects Induced by Dexamehasone

Background: Exposure to glucocorticoids such as dexamethasone (Dex) leads to numerous changes in various biological systems including the reproductive system. The present study investigates the efficacy of curcumin (Cur), an active component of turmeric, to attenuate Dex-induced spetmatogenic defects in the mouse testicles. Materials and Methods: A total of 32 male mice were divided into four g...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

P-49: Protective Effect of Grape Seed Extraction on Dexamethason Induced Spermatogenesis Defect in Mice

Background Exposure to glucocorticoids such as dexamethasone (Dex) leads to numerous changes in various biological systems including the reproductive system .The present study investigates the efficacy grape seeds , source of the most useful groups of plant flavonoids, phenolic procyanids, to attenuate Dex-induced spetmatogenic defects in the mouse testicles. MaterialsAndMethods A total of 32 m...

full text

P-23: The Protective Effect of ZiziphoraTenuior Hydro Alcoholic Extract on Spermatogenesis in Mice

Background: Spermatogenesis is the major factor of male fertility which is pendent on hormones specially testostrone. Testostrone signalling leads to activation of some kinases which are required for progression and maintaining of spermatogenesis. On the other hand, oxidative stress, as the most prevalent factor, influences on fertility. Also, it was shown that chronic oxidative stress in rat t...

full text

P-216: The Protective Effect of Saturejakhuzistanicaagainst Female Mice Follicle Defects Induced by Busulfan

Background: In the past 2 decades, the survival rates for many of the malignancies that affectyoung women have significantly improved. For many of these malignancies, survival rates exceed 80-90%. Therefore, the remote effects of cancer treatment have recently gained worldwide interest, andthe protection against iatrogenic infertility caused by chemotherapy assumes high priority. Busulfan is a ...

full text

effect of oral presentation on development of l2 learners grammar

this experimental study has been conducted to test the effect of oral presentation on the development of l2 learners grammar. but this oral presentation is not merely a deductive instruction of grammatical points, in this presentation two hypotheses of krashen (input and low filter hypotheses), stevicks viewpoints on grammar explanation and correction and widdowsons opinion on limited use of l1...

15 صفحه اول

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 6  issue 2

pages  -

publication date 2012-09-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023